ADME

This course begins with a review of routes of administration, ADME (absorption, distribution, metabolism, & excretion), and the use of in vivo drug concentration-time data to determine key pharmacokinetic parameters, like volume of distribution, half-life and clearance.  The course then emphasizes in vitro assays that allow rapid prediction of [...]

A critical aspect of a drug involves how a drug is dosed and circulates throughout the body of a patient. These qualities are aspects of a drug’s pharmacokinetics or PK. Pharmacokinetics encompasses how a drug is absorbed and flows through a patient until it is ultimately eliminated. While pharmacokinetics [...]

Once a person understands the ideas of drug efficacy, potency, pharmacokinetics, and safety, original research articles can be readily understood. The Journal of Medicinal Chemistry of the American Chemical Society regularly publishes a series of articles called Drug Annotations. These articles summaries a drug discovery program from a pharmaceutical [...]